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KMID : 1094719990040010017
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Biotechnology and Bioprocess Engineering
1999 Volume.4 No. 1 p.17 ~ p.17
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Facile synthesis of 2′,5′-dideoxy-, 2′,3′-dideoxy- and 3′-deoxy-1,N 6-ethenoadenosine nucleosides
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Chae Whi-Gun
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Abstract
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Facile synthetic methods of 2′,5′-dideoxy-, 2′,3′-dideoxy- and 3′-deoxy-1,N 6-ethenoadenosine nucleosides by either an enzymatic dideoxyribosyl transfer reaction or a simple chemical reaction were proposed. The synthetic products were isolated and purified by preparative HPLC and their structures were confirmed by1H NMR (500 MHz) and FAB-MS including high resolution mass measurement. These modified nucleoside analogs have not been reported yet. Therefore, these modified nucleoside analogs are of potential value to be studied further for biological activity such as anticancer or antiviral.
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KEYWORD
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nucleoside phosphorylase, 2′,5′-dideoxy-1, N6-ethenoadenosine, 2′,3′-dideoxy-1, N6-ethenoadenosine, 3′-deoxy-1, N6-ethenoadenosine
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